Indeed, RM has been reported to increase amyloid toxicity, reduce long-term potentiation and synaptic plasticity, and promote brain atrophy in AD (Talboom et al., 2015) and also to exacerbate neuronal damage in a SOD1 murine model of ALS (Zhang et al., 2011). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.