In addition, NAR activates the signaling pathway mediated by nuclear activation factor 2 (Nrf2), a regulator of cellular resistance to oxidants, which has gained attention in the recent years as a target of some neurodegenerative disorders, such as AD and PD (Barone et al., 2011; Speciale et al., 2011; Murphy and Park, 2017). Here, CPSF4 is linked to Alzheimer disease.