Meanwhile, investigations reveal that TMP analogs CXC195 and DT-010 protect dopaminergic neurons against apoptosis through the activation of PI3K/Akt/GSK3β signaling pathway in neurodegenerative disease models, including Parkinson’s Disease (PD) and AD (Chen et al., 2017; Hu et al., 2018; Zhou et al., 2019). Here, AKT1 is linked to Parkinson disease.