Moreover, previous studies have proven that TMP could trigger the PI3K/Akt/GSK3b signaling pathway to manipulate neuronal dendritic arborization and spinogenesis in neurodegenerative diseases, including Parkinson’s Disease (PD) and AD (Chen et al., 2017; Hu et al., 2018; Zhou et al., 2019), implying that other signaling pathways, except for TrkB/ERK/CREB, might take part in the neuroprotection induced by TMP. Here, AKT1 is linked to Alzheimer disease.