The bands depicted that the expression of p-TrkB, p-ERK and p-CREB was remarkably down-regulated in the hippocampus of rats in the BCCAO/CRS group (Figure 8A, t (5) = 12.420; P < 0.0001; Figure 8B, t (5) = 10.470; P = 0.0001; Figure 8C, t (5) = 16.000; P < 0.0001), while this phenomenon was reversed with administration of TMP to some degree (Figure 8A, t (10) = 2.94; P = 0.0148; Figure 8B, t (10) = 3.119; P = 0.0109; Figure 8C, t (10) = 3.699; P = 0.0041). Here, CREB1 is linked to congenital rubella syndrome.