OPTN and amyotrophic lateral sclerosis: Over 100 genes are related to ALS (Abel et al., 2012)1, with more than 30 genes, including SOD1, ALSIN, SETX, SPG11, FUS, VAPB, ANG, TARDBP/TDP-43, FIG4, OPTN, ATXN2, VCP, UBQLN2, SIGMAR1, CHMP2B, PFN1, ERBB4, HNRNPA1, TUBA4A, C9ORF72, CHCHD10, SQSTM1, TBK1, MATR3, NEK1, C21orf2, CCNF, TIA1, and ANXA11, having been replicated in subsequent studies (Mackenzie et al., 2017; Smith et al., 2017; Chia et al., 2018).