AGT and Stroke: COVID-19 downregulation of ACE 2 [10, 12, 31] leads to excessive production of angiotensin II with loss of its breakdown to the vasodilator metabolite angiotensin 1–7, and this excessive angiotensin II have been responsible for endothelial damage and dysfunction as well as oxidative stress and enhances thrombosis that may be one of the possible explanations of stroke occurrence as well as guarded prognosis [32].