PROS1 and COVID-19: Although downregulation in ACE 2 with COVID-19 is reported in many studies and was previously confirmed in 2002 with SARS-CoV as well [10] yet, it is questionable by other studies that states that ACE 2 are still functioning despite being attached to the S protein of SARS-CoV-2, questioning the role of RAS dysregulated mechanism in stroke and COVID-19 [11] and that cytokine surge secondary to the virus infection may over express ACE 2 rather than down regulate it and this facilitates more viral entry to cells [12].