Therefore, this study concluded that exosomal uc.189 secreted by ESCC promoted lymphangiogenesis by down regulating EphA2 expression, and activated p38MAPK in HLEC plays a role in a VEGF-C-dependent manner, and then facilitated tumor cell migration to lymph tube (Figure 7). Here, EPHA2 is linked to esophageal squamous cell carcinoma.