PLS3 and cancer: PLS1 (plastin 1, I-plastin) is expressed in the intestine, colon, kidney and hair cell stereocilia of the inner ear, PLS2 (plastin 2, L-plastin) in hematopoietic cell lineages and many types of cancer cells, and PLS3 (plastin 3, T-plastin), the most abundant isoform, in cells from solid tissues [2, 3].