HSF1 and cancer: We found that among significantly altered pathways were cancer-associated Il-4/Il-1346 and the Hsf1/HSP (heat shock proteins)47 pathways, the Notch pathway known to be induced by ΔNp63 and promote stemness48,49, the extracellular matrix (ECM) components known to promote cancer aggressiveness when overexpressed both, outside and inside of cancer cells50,51, and the FOXO pathway that can be both pro- and anti-oncogenic52 (Fig. 4, Supplementary Fig. 1).