CREBH is induced in mouse liver under conditions of overnutrition, including obesity, insulin resistance (IR), and experimental nonalcoholic fatty liver disease (NAFLD), playing complex regulatory roles in lipid homeostasis (6, 7, 8), hepatic gluconeogenesis (9), clearance of plasma triglycerides (8), and lipid droplet accumulation within hepatocytes (10, 11). The gene discussed is CREB3L3; the disease is obesity due to melanocortin 4 receptor deficiency.