In addition to Fgf21, this analysis yielded several genes with greater fold changes in expression than Fgf21, including those relevant to hepatic lipid, glucose, and energy metabolism: ApoA-IV, solute carrier family 2 (facilitate glucose transporter) member 3 and glycerol kinase 5, as well as hepatocellular carcinoma downregulated mitochondrial carrier protein, which promotes uncoupling of oxidative phosphorylation in liver mitochondria and alleviates hepatic steatosis (25, 26). This evidence concerns the gene GK5 and hepatocellular carcinoma.