APOA4 and fatty liver disease: In addition to Fgf21, this analysis yielded several genes with greater fold changes in expression than Fgf21, including those relevant to hepatic lipid, glucose, and energy metabolism: ApoA-IV, solute carrier family 2 (facilitate glucose transporter) member 3 and glycerol kinase 5, as well as hepatocellular carcinoma downregulated mitochondrial carrier protein, which promotes uncoupling of oxidative phosphorylation in liver mitochondria and alleviates hepatic steatosis (25, 26).