To explore the potential therapeutic value of RFC2 for HCC, ONCOMINE database (www.oncomine.org) and UALCAN database (http://ualcan.path.uab.edu) were used to analyze mRNA expression of RFC2, and Human Protein Atlas (HPA) (https://www.proteinatlas.org/) are used to analyze protein expression. This evidence concerns the gene RFC2 and hepatocellular carcinoma.