Similarly, the promyelocytic leukemia-retinoic acid receptor α (PML/RARα) has two primary NLS, which include one from the PML (159RNKKKK164), and the other from the RARα (486RKVIK490), the NLS of the RARα portion in NLS-RARα is more favorable for the nuclear localization of NLS-RARα [33, 45]. This evidence concerns the gene PML and acute promyelocytic leukemia.