Base on the analysis of bioinformatics software (Circinteractome and TargetScan), we found that circ_0006168 and JMJD1C had complementary binding sequence for miR-194-5p, which stimulated us to assume the ceRNA regulatory network of circ_0006168/ miR-194-5p/JMJD1C in Taxol resistance of ESCC. This evidence concerns the gene JMJD1C and esophageal squamous cell carcinoma.