Finally, the published Th17 transcriptome signatures (CXCL1, CXCL2, CXCL3 and IL-8) [21] and (DUOXA2, S100A7A and CCL20) [22] were applied to the transcriptome from an additional larger published cohort of severe asthma bronchial biopsies from 107 patients (U-BIOPRED) and an unbiased cluster analysis identified 3 clusters, one of which is a distinct Th17-high cluster present in 21 out of the 53 biopsies (40%) (Fig. 1c). Here, S100A7A is linked to asthma.