We employed a novel approach whereby RORγt-sensitive DEGs were identified in a HDM-driven mouse model of mixed Th1, Th2 and Th17 pulmonary inflammation, validated in IL-17 and IL-22 stimulated primary human lung cells and correlated with transcriptome profiles from severe asthma patients in the U-BIOPRED and SARP cohorts. The gene discussed is IL22; the disease is asthma.