Binding of the ABL2 SH3 domain and phosphorylation at Y256 increases N-WASp-mediated actin polymerization and increases localization of ABL and N-WASp to adhesion-dependent cell edge protrusions [85]. ABL kinases can also induce RhoA-dependent actomyosin contractility downstream of HGF/MET signaling to promote migration and invasion in breast cancer cells [90]. The gene discussed is ABL1; the disease is breast carcinoma.