Moreover, an integrated analysis of all the seven types of AS events was performed to create a comprehensive prognostic signature (abbreviated as “ALL”), which consist of PARPBP-24031-ES, NCOR1–39424-ES, COPZ1–22159-RI, ANK3–11845-AP, ITGB5–100223-ES, PHTF1–4284-RI, HSPBP1–52052-AP, TCF12–30783-AP, RPS6KA1–1282-AP, CNST-10497-ES, TMEM25–19023-AA, TMEM25–19017-AA and BTN3A2–75,630-ES (Fig. 3h, Table 1). This evidence concerns the gene HSPBP1 and acute lymphoblastic leukemia.