DMP1 and hypophosphatemic rickets: We determined that the heterozygous DMP1 VUS in our patient was not causal of metaphyseal anomalies for 2 reasons: (1) Only homozygous loss of function variants in DMP1 cause severe hypophosphatemic rickets with autosomal recessive inheritance [13–15], and (2) our patient’s phenotype did not correspond to the DMP1 hypophosphatemic rickets phenotype previously described.