ESR1 and breast carcinoma: Consequently, many expert and organisational guidelines are recommending NET as a ‘bridge to surgery’ for primary resectable ER+/HER2-breast cancer patients during the pandemic, leading to a deviation from the traditional standard of care ‘upfront surgery’ and advising consideration of NET as opposed to NAC for locally advanced ER+/HER2-disease [[26], [27], [28], [29]].