NEFL and familial disease: These results have since been corroborated by the vast majority of studies across both sporadic and familial disease [168, 169, 170, 171, 172, 173], with Schultz et al. [172] observing that similar to CSF NfL, plasma NfL concentrations correlate with white matter damage in the brain, and Ashton et al. [173] demonstrating that plasma NfL correlates strongly with the severity of NFT pathology in AD seen in post‐mortem analysis.