CD8A and neoplasm: A liposome encapsulating phosphoinositide 3‐kinase gamma inhibitor IPI‐549 and photosensitizer chlorin e6 (Ce6) mediates immunogenic photodynamic therapy synergizing with myeloid‐derived suppressive cells (MDSCs)‐targeting immunotherapy, which significantly inhibits colon cancer growth via facilitating the dendritic cells maturation and tumor infiltration of CD8+ T cells while decreasing the tumor infiltration of immunosuppressive regulatory T cells, MDSCs, and M2‐like tumor‐associated macrophages.