Decorin sequesters several growth factors, such as transforming growth factor (TGF)-β1 and directly inhibits several members of the receptor tyrosine kinase (RTK) family, including the insulin-like growth factor receptor I (IGF-IR), the epidermal growth factor receptor (EGFR), and the hepatocyte growth factor receptor (Met), inducing potent tumor repression [23]. The gene discussed is IGF1R; the disease is neoplasm.