Correspondingly, elevated plasma renin independently predicted mortality in cACLD patients adjusted for age, MELD, albumin and HCC before baseline (aHR: 3.15, 95% CI 1.70–5.84; p < 0.001), in contrast to elevated proBNP (aHR: 1.02; 95% CI 0.68–1.52; p = 0.943) and copeptin levels (aHR: 2.44; 95% CI 0.59–10.14; p = 0.221). The gene discussed is NPPB; the disease is hepatocellular carcinoma.