After adjusting for age, sex, MELD, HVPG, albumin, sodium and HCC before baseline, renin (aHR 1.42; 95% CI 1.01–2.01; p = 0.046) and copeptin (aHR: 3.29; 95% CI 1.36–7.95; p = 0.008) remained as independent predictors of mortality. This evidence concerns the gene AVP and hepatocellular carcinoma.