In “Decipher V10.0” database (https://decipher.sanger.ac.uk), several patients with ASD, intellectual disability and ADHD were reported with a duplication/triplication spanning the SHANK2 gene and in experimental systems, a Shank3 transgenic mouse model, modeling a human SHANK3 duplication, exhibited a mania-like phenotype and seizures consistent with synaptic excitatory/inhibitory imbalance [45]. Here, SHANK3 is linked to attention deficit-hyperactivity disorder.