Collectively, SFRP2 high expressing glioblastomas were enriched with mesenchymal subtype tumors, and in vitro SFRP2 induced a proneural-to-mesenchymal subtype gene expression signature transition accompanied by decreased stem cell features, de-regulated proliferation, as well as increased Matrigel invasiveness and sensitivity to apoptotic stimuli. Here, SFRP2 is linked to glioblastoma.