SPI1 and acute promyelocytic leukemia: In accordance with our data, recent studies demonstrated that miR-342 is a direct target of the transcription factor PU.1 leading to an accelerated all-trans retinoic acid-induced myeloid differentiation of APL blasts [49] and that miR-342 is expressed in human and murine macrophages playing an important role in pro-apoptotic signaling after IL-4 stimulation [50].