TNFRSF14 and thyroid gland mucosa-associated lymphoid tissue lymphoma: Taken together, inactivation of both CD274 (PD-L1) and TNFRSF14 in thyroid MALT lymphoma most likely abolishes their negative regulation to T-helper cells, hence enhances their function, leading to exaggerated T-cell help to support malignant B-cells (Fig. 7).