Similarly, medulloblastomas initiated by conditional activation of SmoM2 either prenatally, using hGFAP-Cre, or postnatally, using tamoxifen-inducible Math1-CreER, are histologically and molecularly indistinguishable, but show different propensities for anchorage-independent growth in vitro19. The gene discussed is ATOH1; the disease is medulloblastoma.