TF and cancer: Expression of TFs with motifs enriched in EAC ce-hyperDMRs were downregulated in EAC compared to normal endometrium (Fig. 3b), whereas TFs whose bindings motifs were enriched in EAC cancer-enhancer hypoDMRs (EAC ce-hypoDMRs) were generally upregulated in EAC (Fig. 3c), suggesting that changes in TF expression may help dictate changes in DNA methylation at target motifs in EAC.