Therefore, this site reflects a possible co-opted adipose enhancer that lost DNA methylation in GBM cells, possibly as a result of abnormal upregulation of TCF12 in GBM, resulting in an upregulation of NRP2. Similarly, CD248 (Endosailin) marks tumor-associated pericytes in high-grade glioma56, where blocking CD248 can inhibit the growth and differentiation of perivascular cells57. Here, NRP2 is linked to glioblastoma.