TF and glioblastoma: Clustering ceDMRs by the presence of enriched TF-binding motifs revealed several clusters of DMRs with similar subsets of TF-binding motifs, likely reflecting the high similarity among binding motifs of related TFs, e.g., GATA family (Cluster 3) and SMAD family (Cluster 10) in EAC ce-hyperDMRs (Fig. 4a) and the FOX family (Cluster 4) in GBM ce-hyperDMRs (Fig. 4b).