In these samples NFATc2 was significantly overexpressed in EWSR1-NFATc2 positive sarcomas (mean ± SD: EWSR1-NFATc2 11.3 ± 0.6; CIC-DUX4 5.7 ± 0.9; EWSR1-ETS 5.9 ± 1.1; EWSR1-NFATc2 vs EWSR1-ETSp < 0.0001; EWSR1-NFATc2 vs. CIC-DUX4p < 0.0001; CIC-DUX4 vs. EWSR1-ETSp = 0.34; Supplementary Fig. 2A). The gene discussed is DUX4; the disease is sarcoma.