As an independent assessment of the biologic activity of EWSR1-NFATc2 positive sarcomas in comparison to other Ewing and Ewing family sarcomas, we interrogated two gene expression datasets consisting of 7 EWSR1-NFATc2 positive sarcomas, 14 CIC-DUX4 positive sarcomas, and 117 EWSR1-ETS positive sarcomas downloaded from the GEO database. The gene discussed is DUX4; the disease is sarcoma.