We observed strong associations between PD and the minor allele frequencies of rs3740051 (p = 0.0212) and rs3818292 (p = 0.00978) variants of SIRT1, and rs350843 (p = 0.045), rs350846 (p = 0.025) of SIRT6. However, none of these associations were statistically significant after the FDR correction (p = 0.0832, p = 0.0832, 0.0880 and p = 0.0832 respectively). This evidence concerns the gene SIRT1 and Parkinson disease.