Our study analyzed the correlation between the expression of IRGs and immune check point and found that the expression of PDCD1/PDCD1LG2 was in positive correlation with the expression of DCK and EPO, which revealed that the overexpression of DCK and EPO may upregulate the expression of PD-1/PD-L1, and lead to a suppression of anti-tumor immune response. The gene discussed is PDCD1LG2; the disease is neoplasm.