TP53 and cardiomyopathy: We discovered that many pathways affected in NCCs are also affected in both patient-derived and gene-edited mutant CMs (ECM interactions, p53/MAPK/Rap1 signaling, focal adhesion), while various cardiomyopathy-associated genes were highlighted (Fig. 1g) despite comparable CHD6 levels between the different genotypes (Fig. 1h).