Of the four schizophrenia-associated target genes identified by SMR, GLT8D1 has been reported to be associated with schizophrenia and implicated in synapse function50, KCNJ13 has been reported to be associated with neuronal excitability51, and ATP5MD expression downregulated in PFC brain tissues of schizophrenia patients in our meta-analysis was also observed in PsychEncode consortium (P = 0.019) at transcript level52. The gene discussed is LYPD4; the disease is schizophrenia.