Previously, ATP5MD was reported to be associated with white matter hyperintensities (WMH)53, which have been associated with both schizophrenia and mood disorders, particularly bipolar disorder54; a recurrent ATP5MD splice-site founder mutation in the Ashkenazi Jewish population have been report to impair mitochondrial complex V dimerization and ATP synthesis55. Here, ATP5MK is linked to Hyperintensity of cerebral white matter on MRI.