Together with reports that CNNM2, NT5C2, AS3MT, and BORCS7 in the 10q24.32 locus are also involved in the brain development13,37,62,64, these results constitute important mechanistic components that link schizophrenia-associated genetic variants in the 10q24.32 locus to the impairments in adenosine system modulates and then to the profound effects on neuronal function such as highly energy consuming neurodevelopment process. This evidence concerns the gene NT5C2 and schizophrenia.