Further, the observation that N-specific EM CXCR3+CD8+T cell responses with an IFNγ+CD107a+ Th1 profile were associated with nonhospitalization during symptomatic COVID-19 suggests a favorable immune response when the N protein is targeted by CD8+T cells, and that these responses can migrate towards infected tissues. The gene discussed is IFNG; the disease is COVID-19.