The overlapping gene set included key AD-related genes such as Cst7, Apoe and Tyrobp, and Trem2 and was substantially enriched for Hif1a-related genes such as Gapdh, Igf1, Aldoa, Pkm and Ldha (Supplementary Fig. 5f, g). The gene discussed is TREM2; the disease is Alzheimer disease.