As observed in the mouse gene expression signature associated with XO4+ microglia, we found transcriptional changes to AD GWAS risk genes and their interacting partners: TREM2, APOE, TYROBP and a number of Hif1a regulon target genes including ALDOA, LDHA and PKM encoding for the enzymes: aldolase, lactate dehydrogenase, pyruvate kinase (Supplementary Data 8). The gene discussed is TYROBP; the disease is Alzheimer disease.