Several recent studies suggested AD-specific gene upregulation of TREM2, TYROBP, CLEC7A, CD68, CD34, SPP1 and various MHC Class II genes10,63 and positive LPL staining in ThioS+ (plaque-associated) microglia in 4 out of 5 human AD patients tested13. This evidence concerns the gene TYROBP and Alzheimer disease.