Analogous to 5xFAD mice, we observed that plaque-associated microglia in human AD patients contained modestly, but significantly less PSD95 staining than in non-plaque-associated microglia from the same brain region (p = 0.02, 1-tailed one-sample t-test; Supplementary Fig. 12c). Here, DLG4 is linked to Alzheimer disease.