Hub genes of the turquoise module included one GABA receptor encoding genes such as Gabrb1, one glutamate receptor gene (Grid2) and genes tightly associated with synaptic development and autism (Nrxn1, Lrfn5, Plcb1, Erc2, Frmpd4, Tanc2, Ctnnd2, Dmd). The gene discussed is PLCB1; the disease is autism.