UPF1 and colorectal carcinoma: In addition, univariate and multivariate COX regression analysis suggested that high expression of UPF1 (HR = 3.719; 95% CI = 1.313 to 10.529; P = 0.013) and poor differentiation (HR = 2.927; 95% CI = 1.186 to 7.222; P = 0.020) were independent prognostic risk factors for recurrence in CRC (Fig. 1f, g).