Here, we further confirmed WNT upregulation in ccRCC cells by showing the elevated mRNA levels of downstream targets, such as CCND1, CD44, and TCF4. It is worth noting that combinations of SHH and WNT inhibitors have strong suppressive effects on cell proliferation, migration, and invasion in ccRCC. The gene discussed is CD44; the disease is nonpapillary renal cell carcinoma.