SHH and neoplasm: In addition, Kaplan–Meier analyses carried out by using the dataset from Kaplan–Meier plotter revealed that the patients with high levels of SHH targets (GLI1 and PTCH1) or WNT transcription factor (β-CATENIN) or WNT targets (CD44 and TCF4) all showed poorer survival than those with low expression, indicating that aberrantly activated SHH and WNT signaling indeed promote tumor progression in ccRCC (Fig. 6B).