In addition, Kaplan–Meier analyses carried out by using the dataset from Kaplan–Meier plotter revealed that the patients with high levels of SHH targets (GLI1 and PTCH1) or WNT transcription factor (β-CATENIN) or WNT targets (CD44 and TCF4) all showed poorer survival than those with low expression, indicating that aberrantly activated SHH and WNT signaling indeed promote tumor progression in ccRCC (Fig. 6B). The gene discussed is TCF4; the disease is nonpapillary renal cell carcinoma.