However, the knockdown of NBR1, which is involved in MHC-Ι down-regulation in pancreatic cancer cells, did not exert any effect, excluding NBR1 as a receptor for ORF8-mediated MHC-Ι degradation (SI Appendix, Fig. S4 G and H) (38). The gene discussed is HLA-C; the disease is pancreatic neoplasm.