MLANA and melanoma: This vitiligo is assumed to be caused by MART-1 specific targeting of normal skin cells by T cells, which could be enhanced by DC vaccination Hence, the observed autoimmunity represents on-target, off-tumor killing, which demonstrates efficient targeting or MART-1 antigen in vivo, suggesting that MART-1 targeting of the tumor may also have played a role in preventing relapse of melanoma in this patient.