They also experienced toxicities caused by high-dose IL-2 therapy that resolved by 8–10 days after cell infusion, except for two patients (TIL#177 and #351): one experienced reaction to TIL infusion, with fever, chills, and peripheral edema, and the other experienced grade 2 and grade 3 capillary leak syndrome, respectively. This evidence concerns the gene IL2 and capillary leak syndrome.