TYR and neoplasm: Although T cells recognizing patient-specific mutations are generally found in the tumor, TIL recognizing tumor antigens shared between patients and aberrantly expressed by the tumor, such as melanoma antigen recognized by T cells 1 (MART-1), gp100, and tyrosinase, are also prevalent.22 23 Preclinical mouse modeling demonstrated the extended persistence of adoptively transferred gp100-reactive T cells when combined with antigen-specific DC vaccination resulting in superior tumor control.24