Transferred MART-1 reactive TIL have been shown to be able to persist at high levels in the blood for extended period (>150 days), maintaining cytotoxic antitumor function.41 Because of the high likelihood of the presence of MART-1 specific TIL in the tumors of HLA-A0201+ melanoma patients and its demonstrated value as tumor antigen we chose MART-1 as antigen for our study. Here, MLANA is linked to melanoma.