Enhanced repetitive motor learning on the rotarod is observed in several autism mouse models with prominent behavioral inflexibility, including MECP2-duplication (Collins et al., 2004; Sztainberg et al., 2015), neuroligin-3 (Rothwell et al., 2014), 15q duplication (Nakatani et al., 2009), PTEN (Kwon et al., 2006), and CNTNAP2 mice (Peñagarikano et al., 2011), providing a robust model behavior for studying the abnormal consolidation of repetitive motor routines. This evidence concerns the gene MECP2 and autism.