CD4 and psychotic disorder: They found that PLWHIV and psychosis were more cognitively impaired than HIV-negative psychotic patients at baseline, and although there was some improvement with treatment, they remained more impaired at 6 months, suggesting that HIV worsened cognitive dysfunction in psychosis.13 While earlier studies have suggested that psychosis and impairment in cognition were later manifestations of HIV, the Ugandan study demonstrated that both these conditions occur early, as shown by the average CD4 count of 305 cells/μL and the intermediate WHO staging of disease presentation.