CD4 and HIV-1 infection: Park et al. performed the first genome-wide CRISPR/Cas9 screen in a CD4+ T cell line model to identify HIV-1 host dependency factors due to its susceptibility to HIV-1 infection [61] whilst Rathore et al. used the J-Lat 10.6 cell line to identify novel latency promoting factors in HIV-1 infection [62]; a model Jurkat T-cell-derived cell line used as a model for HIV-1 latency, containing a single integrated, replication-incompetent HIV-1.