Interestingly, in non-canonical IDH1-mutated (IDH1-R132L) or IDH2-mutated (IDH2-R172K, IDH2-R172W, IDH2-R172S) oligodendrogliomas with 1p/19q codeletion, loss of H3K27me3 was never observed. Here, IDH2 is linked to oligodendroglioma.