Likely, human WJ-MSC secretome showed anti-proliferative and apoptosis-inducing effects on human bladder cancer T24 cells in vitro and bladder cancer experimental models mediated by restraining phosphorylation of Akt protein kinase and upregulating p53/p21 and cleaved caspase 3 [174]. This evidence concerns the gene CASP3 and urinary bladder carcinoma.