We attempt to reinforce a potential relevant role of a der(17) chromosome in the pathogenesis of AML M2, which contains in our patient the RUNX1/RUNX1T1 fusion gene: karyotype 46,XX,del(8)(q21q22),der(17)(21qter->21q22::8q22->8q21::17p13 > 17qter),der(21)t(17;21)(p13;q22). This evidence concerns the gene RUNX1 and acute myeloid leukemia.