MAPT and Alzheimer disease: Accordingly, acute manipulation of body temperature leads to strong modulation of AD neuropathology in mice: hypothermia induced by cold exposure increases both tau phosphorylation and amyloid-β (Aβ) pathology and decreases synaptic proteins, while restoring normothermia by exposure to higher room temperature reverses memory and anxiety-like behavior and reduced Aβ42 peptide levels in 3xTg-AD mice [9].