SLC2A1 and Alzheimer disease: While we did not detect any effect of the CL-316,243 treatment, GLUT1 levels were decreased in the hippocampus of 3xTg-AD mice compared to NonTg mice, at both the endothelial (50 kDa) and astrocytic (45 kDa) isoforms (Additional File 2), corroborating defects in glucose uptake, changes in blood-brain barrier transporters, and decreased cerebral vascular volume observed in this mouse model of AD [77–80].