EZH2 and neuropathic pain: Moreover, we identified that microglial H3K27me3 or EZH2, rather than functioning as a repressor, mediate CGRP-induced proinflammatory gene expression, and therefore EH2 inhibitor or CGRP antagonist diminishes microglial activation and attenuates the development of allodynia in rats with CCI-induced neuropathic pain.