IGHE and asthma: Today, clinical guidelines recommend testing severe asthma patients for multiple biomarkers, i.e. blood and sputum EOS, FeNO, IgE (thresholds: blood EOS ≥ 150 cells/μL; FeNO ≥ 20 ppb; IgE ≥ 30 IU/mL) especially in presence of refractory disease with underlying Type 2 inflammation [1].