Herein, we present our extended study on the activity of 1-benzylamino-2-hydroxyalkylmultifunctional anti-AD agents using an in cellulo thioflavin S (ThS) assay in recombinant Escherichia coli cells overexpressing Aβ42 peptide and tau proteins.24 We also performed molecular modeling studiesto investigate possible interactions of the tested compounds withAβ and tau proteins and for selected compounds kinetic aggregationstudies and dissagregation studies in vitro usingAβ40. Here, MAPT is linked to Alzheimer disease.