Furthermore, we observed that in several breast cancer cell lines, total NEAT1 and NEAT1_2 were not proportionally increased upon hypoxia, and the breast cancer cell lines with high levels of eNEMAL expression (Fig 4A) generally showed a bigger increase of the NEAT1_2 portion compared to the total NEAT1 increase upon hypoxia (S5 Fig). Here, ENEMAL is linked to breast cancer.