In addition, it was revealed that restored miR-499-5p or depleted Sox6 alleviated lung tissues pathology, reduced lung injury score, collagen fibers and the degree of pulmonary fibrosis, and reduced TUNEL positive cells, Caspase-3 and Caspase-9 protein expression in lung tissues of sepsis-induced lung injury mice. This evidence concerns the gene CASP3 and Sepsis.